SGS, a leading life sciences, pharmaceutical, clinical and bioanalytical contract solutions provider, announced that it has successfully implemented advanced techniques for the collection and use of Peripheral Blood Mononuclear Cells (PBMCs) for early phase clinical trials at its Clinical Pharmacology Unit (CPU) in Antwerp, Belgium, and also further strengthening its offer in the areas of infectious disease therapeutics and vaccines.
Demand in the biopharmaceutical industry for R&D in immunology and oncology therapeutics continues to grow, with additional parameters now required for clinical trials beyond traditional pharmacokinetic (PK) and pharmacodynamic (PD) parameters. In today’s research, collection and use of peripheral blood mononuclear cells (PBMC) has become a strategic and reliable analytical tool.
PBMCs are already widely used to study various aspects of pathology and biology in vitro, but are now also more and more used in clinical studies in immunology (including auto-immune disorders), as well as infectious diseases, hematological malignancies, vaccine development and transplant immunology. They are also used in high-throughput screening, neovascularization, human body defense mechanism studies, and the analysis of biological effects on tissue and organs and chemokine effects on adipocytes and muscles.
The use of PBMCs within clinical trials poses significant operational challenges, as the cells demand intensive handling techniques. After isolation, the PBMCs must be cryopreserved immediately, and in addition have a determined timeline to be handled due to viability and recovery issues.
SGS provides clinical research and bioanalytical testing with a specific focus on early stage development and biometrics. Delivering solutions in Europe and in the America, SGS offers clinical trial (phase I to IV) services encompassing drug development consultancy, clinical project management and monitoring, biometrics, PK/PD modeling and simulation, and regulatory and medical affairs services. SGS has its own Clinical Pharmacology Unit in Belgium, including a human challenge testing facility and two phase I patient units based in Belgium and Hungary. SGS has a wealth of expertise in First-In-Human studies, viral challenge testing, biosimilars and complex PK/PD studies, with a therapeutic focus on infectious diseases, vaccines and respiratory.
SGS, formerly Société Générale de Surveillance (French for General Society of Surveillance), is a multinational company headquartered in Geneva, Switzerland which provides inspection, verification, testing and certification services. It has more than 95,000 employees and operates over 2,400 offices and laboratories worldwide.