Scientists at the Institute of Cytology and Genetics in Novosibirsk have developed a technology for effective cancer treatment, which allows to reduce the dose of chemotherapy several-fold.
The team of Laboratory of Induced Cellular Processes headed by Sergey Bogachev, the Doctor of Biological Sciences, worked for several years to develop a technology named “Karanahan” (“One that kills the cause”). It is based on the vulnerability of cancer stem cells in certain periods of their life cycle.
“While studying the properties of malignant stem cells, our scientists discovered their unique ability to capture extracellular DNA fragments. Further studies have shown that, if these fragments are introduced into the cell after a certain period of time following the exposure to cytostatics (chemotherapy), they prevent the cell to complete its recovery process and the cell dies,” said the experts.
According to the Institute, the authors of the new technology also called it “3+1,” as the first three doses of the drug introduced into the tumor kill most of the stem cancer cells, and the fourth dose destroys the remaining ones. The new technology has proved successful in treating cancer in mice, as well as human glioblastoma cell cultures.
The study demonstrated that there were some differences between the cell life cycles of different types of tumors. Therefore, each tumor requires its own schedule of drug administration.
The Institute also reported that the new technology had successfully passed through all preclinical studies and was ready for clinical trials.