AbCellera Biologics (Vancouver, Canada) announced the successful completion of the first phase of its collaboration with Denali Therapeutics (San Francisco, USA). Under the collaboration, AbCellera applied its single-cell screening technology to discover hundreds of novel monoclonal antibodies with specific binding properties against a genetically-validated target for neurodegenerative disease.
AbCellera performs ultra-deep screening of natural immune repertoires from any species to discover antibodies from millions of single cells per run, including plasma cells, B-cells and antibody-secreting cells. AbCellera’s platform supports a wide array of single-cell antibody selection assays, combining multi-step and multiplexed binding measurements, and live-cell assays. The combination of speed, screening depth, and greater specificity generates thousands of high-quality antibodies, and translates to successful discovery against difficult targets such as membrane proteins, GPCRs and ion channels.
Beyond its core microfluidic screening technology, AbCellera capabilities integrate expertise in animal immunizations for any species (including humanized rodent platforms), assay design, bioinformatic analysis using a proprietary suite of software and visualization tools, and antibody characterization for developability and engineering. The approach has been validated in multiple partnerships with pharmaceutical and biotechnology companies, proving successful when other technologies, including hybridoma, display technologies and emerging B cell selection platforms, have fallen short.
AbCellera is a privately held company that engages in partnerships to discover and develop next-generation therapeutic antibodies. AbCellera’s single-cell platform integrates end-to-end capabilities for therapeutic antibody discovery through a combination of technologies including proprietary immunizations, microfluidics, high-throughput imaging, genomics, computation, and laboratory automation.
Denali is a biopharmaceutical company developing a broad portfolio of therapeutic candidates for neurodegenerative diseases. Denali pursues new treatments by rigorously assessing genetically validated targets, engineering delivery across the blood-brain barrier and guiding development with biomarker monitoring to demonstrate target engagement and select patients.