Researchers said that biocompatible implants might be widely used in medicine for replacing body tissues and elements of vital internal organs ranging from finger joints to heart valves.
The technology allows creating a polymer implant built in tissue and unrecognizable by the cells of immune system, helping to avoid any foreign body reaction. This is achieved by creating a solid strong protein monolayer active coating compatible with the patient’s immune system.
“The old-style implant is similar to a splinter, when the body continuously signals its discomfort and, as a result, there is a great risk of rejection. This is because the cells of immune system accept only their own proteins and view everything else with suspicion. New implants do not have protein holes, so they successfully “grow into” the body tissues and do not require subsequent replacement,” said the developers.
The technology is being created within the international research team involving the scientists of Imbiocom, a small innovative enterprise of Perm State National Research University, together with their colleagues from the Mechanics and Mathematics Faculty of the Perm Classical University, Perm State Medical University, Institute of Continuous Media Mechanics, Institute of Genetics of Microorganisms of the Ural Branch of the Russian Academy of Sciences, and the University of Sydney.
The development activities continued for more than 10 years, and the project involved several generations of researchers, both experienced experts and young scientists. At this point, the work of scientists is at the stage of experimental laboratory studies in animals.