Celtaxsys expands its pipeline of anti-inflammatory medicines

| By | Drug Development
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Celtaxsys, Inc., a clinical stage pharmaceutical development company focused on advancing treatments for patients with rare inflammatory diseases, announced the issuance of four new patents.

Celtaxsys extended its leadership position in development of a robust pipeline of inhibitors of Leukotriene A4 Hydrolase (LTA4H), the key rate limiting enzyme in production of the inflammatory mediator Leukotriene B4 (LTB4).  LTB4 is a potent mediator of neutrophil activity and when over-expressed, can lead to hyper-activation of neutrophils, resulting in sustained inflammation, tissue damage and reduced organ function, including in the lungs of CF patients. By modulating the over-production of LTB4, acebilustat and second generation LTA4H inhibitors, have the potential to return neutrophil response to a more healthy state (homeostasis), thereby reducing immune mediated morbidity and mortality. These new patents cover core intellectual property to 2034 before addition of extensions.

New patent covers use of the company’s flagship anti-inflammatory drug candidate, acebilustat, for treatment of cystic fibrosis (CF). This patent expands and extends the previously issued intellectual property portfolio surrounding acebilustat composition of matter. Acebilustat is the most advanced anti-inflammatory drug candidate in the CF pipeline. It is currently being studied in a Phase 2b trial (EMPIRE-CF) testing its ability to stem lung function decline and reduce pulmonary exacerbations over 48 weeks of treatment. The trial is fully enrolled and topline results are expected in mid-2018.

Three additional patents cover new compositions of matter for second generation LTA4H inhibitors. These second generation compounds bolster the company’s LTA4H inhibitor platform covering novel compositions that provide an expanded array of properties to facilitate development of topical, inhaled and parenteral formulations as well as providing differential selectivity across functions of LTA4H. Additional patent filings are planned as Celtaxsys continues to extend its leadership position in the field of LTA4H inhibition.

SOURCE: globenewswire
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