Enterome received the budgeting for its drug development programs

| By | Clinical Trials, Drug Development, Investments
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ENTEROME SA, a French clinical-stage biotech company pioneering innovative therapies to treat microbiome-associated diseases with a focus on inflammatory bowel diseases (IBD) and immuno-oncology (IO) indications, raised €32 million in a Series D financing.

The proceeds of the fundraising will be used primarily to progress two proof-of concept clinical trials of Enterome’s lead development programs, a Phase 2 study of the Company’s oral FimH blocker EB8018 for the treatment of Crohn’s disease, and a Phase 1b study of EO2315, a novel immuno-oncology candidate, in patients with aggressive brain cancer (glioblastoma multiforme). In addition, Enterome will pursue the development of the next generation of its proprietary metagenomics drug discovery platform, reinforcing its leadership in the discovery and development of new therapeutic leads and targets for microbiome-associated diseases and expanding the reach of its technology platforms.

In conjunction with its equity financing, Enterome has entered into an agreement with the European Investment Bank (EIB) for access to a €40 million loan facility to further support the acceleration of its pipeline and technology development.

Enterome’s EB8018 is a novel, first-in-class oral small molecule that is gut-restricted and minimally absorbed into the bloodstream. It represents a non-biologic, non-steroidal, non-immunomodulatory approach for the treatment of Crohn’s Disease.

EO2315 is the lead candidate originating from Enterome’s technology platform, which is being applied to discover novel bacterial antigens that display similarities with cancer antigens. Such bacterial antigens have been shown to trigger a robust immune response against host antigens specifically expressed in tumors in animal models, thus providing innovative solutions to making cancer cells the target of the adaptive immune system.

Enterome has already demonstrated that EO2315 generates a strong immune response against an undisclosed tumor target, resulting in potent tumor cell-killing ex vivo and controlled tumor growth in vivo when combined with a checkpoint inhibitor.

Pierre Belichard, Chief Executive Officer of Enterome, said: “We are very pleased to receive the funding and support from this group of current and new investors, who have recognized the potential, versatility, and uniqueness of our microbiome-derived drug discovery platform. The microbiome influences many areas of human disease through its effects on the immune system, and we believe that many new therapies will be discovered based on a greater understanding of its function. Enterome, which is at the forefront of this approach, is already developing two exciting programs based on this knowledge and this financing will allow us to progress these programs through the major inflection points of clinical proof of concept, and to expand our clinical work to additional inflammatory bowel diseases and oncology indications.”

SOURCE: enterome
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