Warp Drive Bio, Inc., a drug discovery company developing therapeutics that exploit the molecules and mechanisms of nature, announced today that it has formed a strategic collaboration with Roche to discover and develop multiple novel classes of antibiotics.
The serious global health threat of multi-drug-resistant bacterial infections has created an urgent need for new antibiotics with novel structures and mechanisms of action.
Under the collaboration, Warp Drive will deploy its proprietary Genome Mining™ Platform to advance multiple novel classes of antibiotics with activity against clinically important, drug-resistant, Gram-negative pathogens. The company’s platform enables access to natural product drugs that have not been analyzed previously, owing to historical technology limitations. Warp Drive is identifying and evaluating over one hundred novel classes of potential antibiotics that were previously undiscovered and thus never analyzed for their impact on human health. There are currently ten classes of natural antibiotics that have been approved for patient use as compared to five classes of synthetic antibiotics. The last antibiotic from a novel natural class approved by the FDA was daptomycin, discovered more than 30 years ago.
“We are committed to bringing urgently needed novel antibiotic medicines to patients, and we are delighted to be collaborating with Roche in that goal,” said Laurence Reid, Ph.D., CEO of Warp Drive Bio. “Antimicrobial resistance is an extraordinary threat to global human health, and Warp Drive’s unique platform allows us to access a vast reservoir of uncharacterized natural products from which to identify novel antibiotics.”