Researchers at the Perm University started developing methods to synthesize new promising antibiotic compounds. The scientists are studying the properties of new quinoxaline derivatives. The compounds of this class are successfully used in medical practice as antibiotics, including those against TB. The new method of synthesis will allow to obtain compounds capable of affecting the strains that have already formed high resistance to known antibacterial substances.
“Today, new antimicrobial agents are created primarily by modifying chemical structure of already known antibiotics. This approach is effective, as it allows to obtain compounds with known mechanism of action. However, pathogenic microorganisms have learned how to adapt quickly to “familiar” drugs based on old chemical structures. Therefore, strategically, it is more beneficial to create antibacterial agents based on new chemical structures that act differently. Quinoxaline derivatives have already proven themselves as potential biologically active compounds,” said Ekaterina Stepanova, Project Leader, Candidate of Chemical Sciences, Researcher at the Faculty of Chemistry of Perm State National Research University.
The project of chemical researchers from Perm university is notable for wide availability of source materials and waste-free production. In addition, the development will also address the fundamental scientific problems, such as studying the mechanisms of organic reactions involving acylimidoylketene, an intermediary substance with short lifetime and high reactivity; and studying the mechanisms of antibacterial action of new substances.