Enterin Inc., a Philadelphia-based biotechnology company developing novel compounds to treat Parkinson’s disease (PD), today announced the completion of a $12.7 million Series A financing round. The financing included new investors New Ventures III, as well as the participation of existing investors.
“We are absolutely thrilled to have the support of New Ventures III and our current investors, and view the caliber of our investors as validation of the potential of our platform technology to transform the course of PD and of other neurodegenerative diseases,” said Michael Zasloff, M.D. Ph.D., Founder, Chairman and CEO of Enterin. He added, “The proceeds from this financing will enable us to complete the ongoing Phase 2 study in PD, further expand our understanding of the role of alpha-synuclein (aS) in the pathology of PD and begin to explore other indications. We are very excited about working with this outstanding group of investors, and bringing their deep expertise and guidance to bear as we progress our development.”
The announcement coincides with an ongoing Phase 1/2a clinical trial, sponsored by Enterin Inc., targeting the accumulation of aS in the enteric nervous system. The trial is examining the safety, tolerability, pharmacokinetics, and pharmacodynamics of ENT-01 to relieve constipation associated with Parkinson’s disease.
“While the study is focused on functional improvement of the enteric nervous system, we are closely monitoring central nervous system symptoms such as sleep, REM-behavior disorder, depression, fatigue and even motor symptoms,” said Denise Barbut, M.D. F.R.C.P., Co-Founder, President and Chief Medical Officer of Enterin. She added, “The drug has the potential to slow the progression of PD and of other neurodegenerative disorders in which dysfunction of the enteric nervous system plays a part.”
Research recently published by Dr. Zasloff and collaborators demonstrated that squalamine both reduced the formation of toxic αS clumps and their toxicity in animal models of Parkinson’s disease.