The researchers at the Faculty of Biology and A.N. Belozersky Institute Of Physico-Chemical Biology in M.V. Lomonosov Moscow State University used a mouse model to test SkQ1, a mitochondria-targeted antioxidant that facilitates diabetic wound healing.
The findings revealed that SkQ1 significantly accelerated wounds healing in mice. It accelerated the wound epithelization, formation of granulation tissue, and stimulated the growth of blood vessels to restore the disturbed blood circulation, which is extremely important for the healing of diabetic wounds. The experiments conducted on cell cultures, as well as a thorough histological testing of these wounds, showed that SkQ1 normalizes virtually all key stages of wound healing, which proves the crucial role of mitochondrial reactive oxygen species in the pathogenesis of diabetic wounds.
These findings can be used in development of an effective medicine for diabetic wound healing. Such drug could be an oral dosage form for systemic use or a gel for topical application to damaged skin areas to promote diabetic wound healing.